After 18 matches in the EPL, United lead with 44 points, Chelsea are second on 42 and Liverpool third on 31.
A goal from captain Raul allowed Real Madrid to snatch a 1-0 win against Valencia in the Primera Liga.
Bayern Munich, Liverpool, PSV Eindhoven and Valencia reached the knockout round of the Champions League with two group matches to spare.
Barcelona scored a high-class 3-0 win over city rivals Espanyol to win the Super Cup.
Transcripts of Prem Panicker's chat on Thursday.
Cristiano Ronaldo's late header prevented the twice European champions' going down to their worst league defeat this century.
Champions Barcelona scored an easy 3-0 home win over high-flying Osasuna in the Primera Liga.
Uruguayan midfielder Fabian Canobbio scored a contentious goal to give promoted Celta Vigo a 3-2 win.
Many of the youth of today are not aware of the Bhopal gas tragedy. In fact, even those (not from Bhopal) who were old enough to understand, have only hazy memories of the world's worst industrial disaster.
Skipper Raul scored from the penalty spot 12 minutes into the second half as Spain escaped with a 1-1 draw.
Valencia will meet Olympique Marseille in the UEFA Cup final after a 1-0 aggregate win over Villarreal.